Denali National Park and Preserve is located in Interior Alaska and contains Denali, the tallest mountain in North America. The park and preserve together cover 9,492 mi² (24,585 km²).

The word "Denali" means "the High One" in the native Athabaskan language and refers to the mountain itself. The mountain was named after president William McKinley of Ohio in 1897 by local prospector William A. Dickey, although McKinley had no connection with the region.

Charles Sheldon took an interest in the Dall sheep native to the region, and became concerned that human encroachment may threaten the species. After his 1907-1908 visit, he petitioned the people of Alaska and Congress to create a preserve for the sheep. (His account of the visit was published posthumously as The Wilderness of Denali, ). The park was established as Mount McKinley National Park on February 26, 1917. Ironically, only a portion of Mount McKinley (not even including the summit) was within the original park boundary. The park was designated an international biosphere reserve in 1976. A separate Denali National Monument was proclaimed by Jimmy Carter on December 1, 1978.