Louisville see Pronunciation below) is Kentucky's largest city. It is ranked as either the 16th or 27th largest city in the United States depending on how the population is calculated (see Nomenclature, population and ranking below). The settlement that became the City of Louisville was founded in 1778 by George Rogers Clark and is named after King Louis XVI of France. Louisville is most famous as the home of "The Most Exciting Two Minutes in Sports": the Kentucky Derby, the widely watched first race of the Triple Crown of Thoroughbred Racing.

Louisville is situated in north-central Kentucky on the Kentucky-Indiana border at the only natural obstacle in the Ohio River, the Falls of the Ohio. Louisville is the county seat of Jefferson County, and since 2003, the city's borders are contiguous with those of the county due to merger.