Southeast Minnesota is the corner of Minnesota south of the Twin Cities metropolitan area extending east. Rochester is the largest city in the area; other major cities include Winona, Owatonna, Faribault, Northfield, Austin, and Red Wing.

Southeast Minnesota is part of the state's First and Second Congressional Districts. Culturally, it is distinct from the Twin Cities in being generally more conservative and staid, with several more diverse areas, such as the college towns of Northfield and Winona. However, the area is becoming more diverse and more politically competitive. Until 2006, the state's only Independence Party legislator was from Southeast Minnesota, Sheila Kiscaden (IP-Rochester, now DFL-Rochester). Formerly a Republican, Kiscaden is now officially a member of the Minnesota Democratic-Farmer-Labor Party.