Port St. Lucie is a city in St. Lucie County, Florida, United States. The population of Port St. Lucie was 88,769 at the 2000 census. According to the 2006 Census estimates, the city proper had an estimated population of 144,159. The city is home to New York Mets spring training and the St. Lucie Mets Florida State League team. Florida Atlantic University has its Treasure Coast campus in the city. Port St. Lucie has had the problem of being hit by three major hurricanes within 2 years: Hurricane Frances, Hurricane Jeanne (which both hit the city by the eye), and Hurricane Wilma.

According to the United States Census Bureau, the city has a total area of 198.6 km² (76.7 mi²). 195.6 km² (75.5 mi²) of it is land and 3.0 km² (1.1 mi²) of it (1.50%) is water. As of the census of 2000, there were 88,769 people, 33,909 households, and 25,736 families residing in the city. The population density was 453.7/km² (1,175.1/mi²). There were 36,785 housing units at an average density of 188.0/km² (487.0/mi²). The racial makeup of the city was 87.88% White, 7.09% African American, 1.24% Asian, 0.23% Native American, 0.03% Pacific Islander, 1.77% from other races, and 1.76% from two or more races. Hispanic or Latino of any race were 7.52% of the population.