Port Charlotte is a census-designated place (CDP) in Charlotte County, Florida, United States. The population was 46,451 at the 2000 census. According to the United States Census Bureau, the CDP has a total area of 61.8 km² (23.9 mi²). 57.7 km² (22.3 mi²) of it is land and 4.1 km² (1.6 mi²) of it (6.66%) is water.

As of the census of 2000, there were 46,451 people, 20,453 households, and 13,601 families residing in the CDP. The population density was 805.3/km² (2,085.9/mi²). There were 23,315 housing units at an average density of 404.2/km² (1,047.0/mi²). The racial makeup of the CDP was 89.23% White, 6.53% African American, 0.28% Native American, 1.14% Asian, 0.05% Pacific Islander, 1.18% from other races, and 1.59% from two or more races. Hispanic or Latino of any race were 5.16% of the population. There were 20,453 households out of which 20.8% had children under the age of 18 living with them, 53.2% were married couples living together, 10.1% had a female householder with no husband present, and 33.5% were non-families. 28.2% of all households were made up of individuals and 18.6% had someone living alone who was 65 years of age or older. The average household size was 2.25 and the average family size was 2.71.