Moultrie, nicknamed The City Of Southern Living, is a city and the county seat of Colquitt County. Moultrie is an agricultural community set in the Southern Rivers part of the State of Georgia. It is well known for its many antique shops and has been styled "The Antique Capitol of South Georgia". Moultrie is a peaceful city of beautiful landscapes, huge sprawling oak trees and stately homes. Attractive vistas begin at the heart of Moultrie in the downtown square. In outlying areas of the county, there are vast farmlands and rolling area of both cotton and tobacco crops. Moultrie is also the home of US Senator Saxby Chambliss.

Located in Southwest Georgia, Moultrie is in the center of Colquitt County, 24 miles (39 km) west of Interstate 75 - about 200 miles (300 km) south of Atlanta and 60 miles (100 km) north of Tallahassee, Florida. The city is geographically in the middle of Albany to the NW, Tifton to the NE, Thomasville to the SW, and Valdosta to the SE. According to the United States Census Bureau, the city has a total area of 36.9 km˛ (14.2 mi˛).