Indian River County is a county located in the U.S. state of Florida. As of 2000, the population was 112,947. The U.S. Census Bureau 2005 estimate for the county is 128,594. Its county seat is Vero Beach, Florida. According to the U.S. Census Bureau, the county has a total area of 1,598 km² (617 mi²). 1,303 km² (503 mi²) of it is land and 294 km² (114 mi²) of it is water, much of it in the Atlantic Ocean. The total area is 18.43% water.

As of the census² of 2000, there were 112,947 people, 49,137 households, and 32,725 families residing in the county. The population density was 87/km² (224/mi²). There were 57,902 housing units at an average density of 44/km² (115/mi²). The racial makeup of the county was 87.43% White, 8.19% Black or African American, 0.25% Native American, 0.74% Asian, 0.03% Pacific Islander, 2.15% from other races, and 1.21% from two or more races. 6.53% of the population were Hispanic or Latino of any race.