Baltimore is an independent city located in the U.S. state of Maryland on the eastern coast of the United States of America. As of 2005, the population of Baltimore City was 641,943 and the Baltimore-Towson metropolitan area has approximately 2.6 million residents. Baltimore is the largest city in Maryland and serves as the state's major cultural and industrial center. The city is named after the founding proprietor of the Maryland Colony, Lord Baltimore in the Irish House of Lords. Baltimore became the second leading port of entry for immigrants to the United States during the 1800s. The city is a major U.S. seaport, situated closer to major midwestern markets than any other major seaport on the East Coast.

Because there is also a Baltimore County surrounding (but not including) the city, it is sometimes referred to as Baltimore City when a clear distinction is desired.