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Ziprasidone for the Treatment of Generalized Anxiety Comorbidity in Patients With Bipolar Disorder

Ziprasidone for the Treatment of Generalized Anxiety Comorbidity in Patients With Bipolar Disorder


This study would be the first prospective placebo-controlled study to our knowledge of any pharmacotherapy strategy for the treatment of comorbid generalized anxiety (or any comorbid anxiety) in patients with bipolar disorder. Our hypotheses are:(1) ...
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Aripiprazole Associated With Methylphenidate in Children and Adolescents With Bipolar Disorder and ADHD: A Randomized Cross-Over Placebo Controlled Trial

Aripiprazole Associated With Methylphenidate in Children and Adolescents With Bipolar Disorder and ADHD: A Randomized Cross-Over Placebo Controlled Trial


Bipolar disorder (BD) is a chronic disorder that severely affects the normal development of children and adolescents. The disorder is associated with high rates of suicide and high-risk behaviors like sexual promiscuity and drug abuse. Bipolar ...
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Evaluation of Patients With Rapid Cycling Bipolar Disorder

Evaluation of Patients With Rapid Cycling Bipolar Disorder


The purpose of this protocol is to allow for the medical and psychiatric screening of patients with rapid cycling bipolar disorder in order to ascertain (1) that they fit the criteria for the diagnosis; and (2) that they are interested in ...
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Study of Licarbazepine in the Treatment of Manic Episodes of Bipolar Disorder

Study of Licarbazepine in the Treatment of Manic Episodes of Bipolar Disorder


The purpose of this study is to evaluate the effectiveness and tolerability of an investigational drug for the treatment of manic episodes of bipolar disorder. The investigational drug will be given as additional therapy to one of the five following ...
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The Safety And Efficacy Of Risperdal®(Risperidone) Versus Placebo As Add-On Therapy To Mood Stabilizers In The Treatment Of The Manic Phase Of Bipolar Disorder

The Safety And Efficacy Of Risperdal®(Risperidone) Versus Placebo As Add-On Therapy To Mood Stabilizers In The Treatment Of The Manic Phase Of Bipolar Disorder


Risperidone widely used in the treatment of schizophrenia has been shown to be effective in the treatment of manic and mixed episodes associated with bipolar disorders. Antipsychotic drugs like risperidone have also been used as therapeutic agents ...
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A Double-Blind Placebo-Controlled Pilot Study of Citicoline Add-on Therapy in Patients With Bipolar Disorder or Major Depressive Disorder and Amphetamine Abuse or Dependence

A Double-Blind Placebo-Controlled Pilot Study of Citicoline Add-on Therapy in Patients With Bipolar Disorder or Major Depressive Disorder and Amphetamine Abuse or Dependence


Bipolar disorder (BD) is a common and severe psychiatric illness. Drug and alcohol abuse are very common in people with BD and other mood disorders and are associated with increased rates of hospitalization, violence towards self and others, ...
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Proton Magnetic Resonance Spectroscopy in Children and Adolescents With Bipolar Disorder

Proton Magnetic Resonance Spectroscopy in Children and Adolescents With Bipolar Disorder


Choline containing compound (Cho) and creatine + phosphocreatine (Cr) have been found to be greater in the orbitofrontal cortex of depressed adolescents. In addition Cho/Cr has been found to increase in the anterior cingulate in depressed patients ...
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Topiramate Versus Placebo as Add-on Treatment in Patients With Bipolar Disorder in the Outpatient Setting

Topiramate Versus Placebo as Add-on Treatment in Patients With Bipolar Disorder in the Outpatient Setting


Many patients with bipolar disorder (manic-depressive illness) require more than one medication to control their symptoms. This is a 12-week multicenter randomized double-blind placebo-controlled parallel-groupd study to evalute the efficacy and ...
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An Investigation Examining the Evidence for Mitochondrial Dysfunction in the Pathophysiology and Treatment of Bipolar Disorder

An Investigation Examining the Evidence for Mitochondrial Dysfunction in the Pathophysiology and Treatment of Bipolar Disorder


Bipolar affective disorder is a common severe chronic and often life-threatening illness. The depressive phase contributes to the majority of morbidity and mortality in this illness. Impairments in physical and social functioning resulting from ...
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